Pharmacological properties of Clobetasol propionate cream.
Clobetasol induces proteins that inhibit phospholipase A2, inhibits the formation of arachidonic acid and its products of metabolism – leukotrienes, prostaglandins. Clobetasol cream the site of application eliminates flushing, swelling, itching. Perhaps absorption of clobetasol in the systemic circulation when topically applied. In applying clobetasol to large areas of skin absorption is more pronounced. Clobetasol metabolized mainly in the liver; a small portion of the drug is metabolized in the kidneys. Clobetasol is displayed in the urine.
In the study on mice clobetasol teratogenicity was revealed its fetotoxicity when administered subcutaneously maximum dose – 1 mg / kg, when administered at doses of 0.03 mg / kg was found clobetasol teratogenicity. These dosages comprise about 33% and 1%, respectively, of the recommended dose topical ointment clobetasol for human use. The observed malformations: the cleaved skull, cleft palate, and other developmental disorders of the skeleton. Just set teratogenic activity when administered to laboratory animals relatively low dose. It is also found that certain glucocorticoids have teratogenic activity when applied to the skin of laboratory animals. The local use of teratogenic activity of clobetasol has not been studied. However, given the ability of clobetasol absorption through the skin in vivo were conducted with subcutaneous administration of the drug. In these studies found expressed clobetasol teratogenicity in mice rabbits. The drugs have a higher clobetasol teratogenic potential than drugs glucocorticoids with less activity. The duration of the carcinogenicity study of clobetasol has not been carried out. Clobetasol 0.05 cream propionate mutagenic activity have been identified in the Ames test, using the accounting method of gene conversion in yeast species Saccharomyces cerevisiae. In studies on rats administered 50 mg / kg per day clobetasol. It showed a reduction in the number of viable fetuses, increased cases of resorption of embryos.
- Ointment, cream: chronic eczema, psoriasis (excluding widespread plaque and pustular), discoid lupus erythematosus, lichen planus, skin diseases, which are resistant to treatment with glucocorticoids for less active outdoor use.
- Shampoo: prevention and treatment of relapse of psoriasis of the scalp in adults (except for the distribution and pustular plaque).